PROPERTIES
VEPOLOXAMER
Vepoloxamer, due to its amphiphilic nature, interacts with the lipid bilayer of the cell membrane. This interaction results in a multimodal affect on both cellular and vascular function impacting multiple biologic processes. These are invaluable for POSITIVE therapeutic outcomes.
Scavenging Free Radicals and Quenching Reactive Oxygen Species
Free radicals, including oxygen species, are generated cells during various physiological processes. Vepoloxamer acts as a scavenger for these free radicals; it can bind to and neutralize reactive oxygen species (ROS), preventing them from causing damage to cellular components such as proteins, lipids and DNA.
ROS, including molecules like superoxide radicals and hydrogen peroxide, can induce oxidative stress and damage cellular structures. Vepoloxamer has the ability to quench or reduce the levels of ROS. By doing so, it helps in maintaining cellular homeostasis and preventing oxidative stress.
Reducing Inflammation
Vepoloxamer effectively reduces inflammation by targeting multiple pathways involved in the inflammatory response by inhibiting the propagation of innate inflammatory injury, reducing the infiltration of neutrophils and suppressing cytokine release in irradiated tissues. Furthermore, Vepoloxamer prevents the activation of myofibroblasts, which play a key role in fibrosis.
These processes are interconnected, and the multimodal effects of Vepoloxamer contribute to its potential in various therapeutic applications, particularly in the context of radiation therapy and related medical treatments. Changes of state is how biology works. Single target approaches often miss this outcome.
Radioprotection
As a radioprotectant agent , Vepoloxamer forms a protective barrier on cell membranes, mitigating the harmful effects of radiation by scavenging and neutralizing reactive oxygen species while still allowing effective tumor treatment.
Restoration of Cell Membranes
The lipid bilayer of cell membranes is particularly vulnerable to oxidative damage. Vepoloxamer, with its hydrophobic-hydrophilic associative interaction with cell surface lipid bilayer membranes, can contribute to the protection of these membranes. This is achieved by increasing the packing density of the lipid bilayer and forming a network of intermolecular hydrogen bonds.
Modifying Blood Rheology
Vepoloxamers rheologic properties play a role in mitigating the effects of radiation damage. As an amphiphilic molecule , Vepoloxamer associates with red blood cells and the vascular endothelium, reduces their viscosity and cell-cell interaction. This modification in rheology facilitates improved blood flow to tissues surrounding the irradiated area, enhancing oxygen and nutrient delivery while aiding in the removal of waste products.
